Local Anaesthesia—Before Cocaine

Silent Cocaine Poisoning

Background: Cocaine poisoning is known for causing severe clinical effects such as tachycardia, hypertension, agitation and confusion. Absence of clinical manifestations in cocaine poisoning is unusual. Case report: A 26-year old man, known to be a cocaine addict, declared that he was forced by cocaine dealers to swallow many tablets of cocaine, six hours prior to admission to emergency departm...

Cholinergic Interneurons Control Local Circuit Activity and Cocaine

, 1677 (2010); 330 Science et al. Ilana B. Witten Conditioning Cholinergic Interneurons Control Local Circuit Activity and Cocaine This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission t...

Cholinergic interneurons control local circuit activity and cocaine conditioning.

Cholinergic neurons are widespread, and pharmacological modulation of acetylcholine receptors affects numerous brain processes, but such modulation entails side effects due to limitations in specificity for receptor type and target cell. As a result, causal roles of cholinergic neurons in circuits have been unclear. We integrated optogenetics, freely moving mammalian behavior, in vivo electroph...

Cocaine

Cocaine.

Cocaine, derived from the shrub Erythroxylon coca, was both chemically extracted and reported to be psychotogenic in 1859. Included in the original formulation of ‘Coca-Cola’, it was declared illegal under the Harrison Act of 1914. It has been used as a local anaesthetic and in analgesic cocktails. In one study, the main routes of administration were: smoking, 40%; intranasal, 32%; and injectin...